Mucopolysaccharidoses Type VI &VI Mild (MPS)

MPS VII is one of the least common forms of the mucopolysaccharidoses. The disorder is caused by deficiency of the enzyme beta-glucuronidase (GUSB). In its rarest form, MPS VII causes kittens to be born with hydrops fetalis, in which extreme amounts of fluid are retained in the body. Neurological symptoms may include mild to moderate mental retardation, communicating hydrocephalus, nerve entrapment, corneal clouding, and some loss of peripheral and night vision. Other symptoms include short stature, some skeletal irregularities, joint stiffness and restricted movement, and umbilical and/or inguinal hernias.

The disease is inherited as an autosomal recessive lysosomal storage disorder.

The SNP test for this disease is directed to the gene that codes for the enzyme b-glucuronidase. Many cat breeds are affected by Type VI & VI MILD.

If you have additional questions about testing please feel email us at info@catgenes.org.

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